Hormonal breast augmentation: IGF-1

[twilightsrose]

I can understand that. In doing my own searches on research about IGF, alot of these articles relating to breast cancer's relationship to IGF research came up. It got me thinking about the possible negative side-effects of BE and I felt obligated in sharing. I find most of my information via Google, although it is alot of information to filter through. I found several references to this exact article plus additions to it as well. Afterwards, I found more recent articles and research as well.

A copy of the article in question can be found at www.jsonline.com/alive/news/cancer/2.asp

Thanks, and take care,

Twilightsrose

[fawnmarie]

My personal opinion is that if you have a high risk profile for breast cancer, you're probably safer getting implants than doing hormonal augmentation.

Risk factors:

menarche before 12
menopause after 50
no children
first child after 30
family history

And my suspicion is that other factors will contribute:

poor glucose utilization
poor lymphatic health
birth control pills or other synthetic estrogen

And I really do think bras don't help.

Fawn

[marshall97]

1: Nat Med. 1997 Oct;3(10):1141-4. Related Articles, Links


Comment in:
Nat Med. 1997 Oct;3(10):1081-2.

Growth hormone treatment induces mammary gland hyperplasia in aging primates.

Ng ST, Zhou J, Adesanya OO, Wang J, LeRoith D, Bondy CA.

Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-1770, USA.

The decline of growth hormone (GH) and insulin-like growth factor I (IGF-I) production during aging has been likened to the decrease in gonadal steroids in menopause. The repletion of GH/IGF-I levels in aging individuals is suggested to restore the lean tissue anabolism characteristic of youth. In addition to anabolic effects on musculo-skeletal tissues, GH also stimulates mammary glandular growth in some species, although its effects on primate mammary growth remain unclear. Some clinical observations implicate GH in human mammary growth, for example, gynecomastia occurs in some children treated with GH (ref. 6), and tall stature and acromegaly are associated with an increased incidence of breast cancer. To investigate the effects of GH/IGF-I augmentation on mammary tissue in a model relevant to aging humans, we treated aged female rhesus monkeys with GH, IGF-I, GH + IGF-I or saline diluent for 7 weeks. IGF-I treatment was associated with a twofold increase, GH with a three- to fourfold increase, and GH + IGF-I with a four'-to fivefold increase in mammary glandular size and epithelial proliferation index. These mitogenic effects were directly correlated with circulating GH and IGF-I levels, suggesting that either GH or its downstream effector IGF-I stimulates primate mammary epithelial proliferation.

PMID: 9334728 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

M97

[marshall97]

1: J Mammary Gland Biol Neoplasia. 2000 Jan;5(1):7-17. Related Articles, Links


IGF-I: an essential factor in terminal end bud formation and ductal morphogenesis.

Kleinberg DL, Feldman M, Ruan W.

Department of Medicine, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York 10010, USA. [e-mail]

Growth hormone (GH) is essential for rodent mammary gland development during puberty. It binds to GH receptors in the stromal compartment of the mammary gland and stimulates IGF-I mRNA expression. These findings lead to the hypothesis that GH acts through locally produced IGF-I, which in turn, causes development of terminal end buds (TEBs), the structures that lead the process of mammary gland development during puberty. Subsequent studies have in large measure proven this hypothesis. They include the observations that mammary development was grossly impaired in female mice deficient in IGF-I (IGF-I(-/-) knockout mice), and treatment of these mice with IGF-I plus estradiol (E2) restored pubertal mammary development while treatment with GH + E2 did not. Thus, the full phenotypic action of GH in mammary gland development is mediated by IGF-I. We have demonstrated one effect of GH on the mammary gland that does not appear to be mediated by the action of IGF-I. GH increased the level of estrogen receptor (ER) mRNA and protein in the nuclei of mammary fat pad cells, but IGF-I did not. In addition to the critical role of the GH/IGF-I axis during pubertal mammary development, other data suggest that IGF-I might also be of importance during pregnancy and lactation. In summary, the earliest phase of pubertal mammary development (formation of TEBs) requires IGF-I or GH in IGF-I sufficient animals. No other hormones have been shown to stimulate formation of TEBs unless GH or IGF-I is present. GH-induced IGF-I is of major importance in ductal morphogenesis, and may, in fact, be necessary for later stages of mammary development, as well.

Publication Types:
Review
Review, Tutorial

PMID: 10791764 [PubMed - indexed for MEDLINE]
M97

[marshall97]

Endocrinology. 1995 Mar;136(3):1296-302. Related Articles, Links


Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid.

Ruan W, Catanese V, Wieczorek R, Feldman M, Kleinberg DL.

Department of Medicine, Department of Veterans Affairs Medical Center, New York, New York.

Pubertal mammary development in the rat is largely dependent upon GH and estrogen. We recently showed that insulin-like growth factor-I (IGF-I) can substitute for GH in inducing mammary development in male rats, suggesting that IGF-I mediates GH action. The present study investigated whether IGF-I, like GH, required estradiol (E2) to act or whether IGF-I could substitute for both GH and E2. The effects of IGF-I were tested in the presence and absence of E2. Elvax pellets containing IGF-I or des(1-3) IGF-I were implanted into right lumbar mammary glands of sexually immature, hypophysectomized, oophorectomized female rats, with control BSA-containing pellets in the contralateral glands. After 5 days, both lumbar mammary glands were removed and examined in whole mounts for mammary development by counting terminal end buds and alveolar structures. E2, administered in SILASTIC brand capsules, had no independent effect on mammary development. In the absence of E2, des(1-3) IGF-I had a small, but significant, independent effect on mammary development; native IGF-I was ineffective. The addition of E2 significantly enhanced the effects of IGF-I and des(1-3) IGF-I on mammary development, similar to that noted when E2 was given along with GH. We also studied the effects of E2 and/or hGH on mammary gland IGF-I messenger RNA (mRNA) in hypophysectomized castrated male animals. E2 alone did not increase mammary gland IGF-I mRNA concentrations, but E2 enhanced the effect of hGH on IGF-I mRNA by 4- to 6-fold. These studies indicate that IGF-I can have a small independent effect on mammary development, but like GH, E2 is required for a full effect. They also indicate that E2 is capable of synergizing with GH in the production or expression of IGF-I mRNA, and that the action of E2 on mammary development may take place at multiple sites. If locally produced IGF-I does indeed mediate the action of GH in mammary development, then although E2 is capable of enhancing the effect of GH on IGF-I mRNA, its major effect in mammary development occurs after IGF-I is produced.

PMID: 7867584 [PubMed - indexed for MEDLINE]
M97

[marshall97]

Here are a couple more abstracts on GH/IGF-1 and mammary development. There is a ton of info on PubMed, so I will defer you there if you want more info.
Happy Reading! M97



J Endocrinol. 2001 Jan;168(1):1-23. Related Articles, Links


Growth hormone: roles in female reproduction.

Hull KL, Harvey S.

Bishop's University, Lennoxville, Quebec J1M 1Z7, Canada.

GH, as its name suggests, is obligatory for growth and development. It is, however, also involved in the processes of sexual differentiation and pubertal maturation and it participates in gonadal steroidogenesis, gametogenesis and ovulation. It also has additional roles in pregnancy and lactation. These actions may reflect direct endocrine actions of pituitary GH or be mediated by its induction of hepatic or local IGF-I production. However, as GH is also produced in gonadal, placental and mammary tissues, it may act in paracrine or autocrine ways to regulate local processes that are strategically regulated by pituitary GH. The concept that GH is an important modulator of female reproduction is the focus of this review.

Publication Types:
Review
Review, Academic

PMID: 11139766 [PubMed - indexed for MEDLINE]

[mominator]

D A M N M97, (ha...got past the naughty word list)
You are producing some awesome information! ;D

THANK YOU!

[LadyR]

Truly, I'm no expert, but I think that GABA raises IGF-1 levels. It can be purchased on-line or at your health food store.

[shakira8]

Hi there,I just started taking soy isoflavons,are there any girls that have already tried it?Any results?

[buffy]

Interesting... A lot of ladies here have had to take care of hypothyroid issues before experiencing good growth. It appears (from a google search) that low levels of IGF-1 are associated with hypothyroidism. Wish I had an understandable article to post. What I did find was many articles which mention this fact in passing. Food for thought.