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Post by marshall97 on Nov 30, 2003 12:07:27 GMT -5
Just some more data for those doing their own research. IGF-1 levels seemed to determine a postive outcome for breast growth in this study. Of course, why some of the women had increased levels of IGF-1 in response to the estrogen is not addressed, but it is an interesting correlation, nonetheless. Sorry it is just an abstract at this point in time. I will pull the article on Monday and let you know if there is anything relevant in the remainder of the publication. This might help answer the question as to why some of us respond dramatically to herbs or BO and others of us see NO results, no matter what we do. If our bodies aren't increasing levels of IGF-1 in response to BE, that might be why we don't grow. So, then the question is--why do some women increase levels of IGF-1 in response to estrogen and others do not. I HOPE the full article will give some insight into this. HAPPY READING!!
Gynecol Endocrinol. 1998 Apr;12(2):123-7. Related Articles, Links
Hormonal breast augmentation: prognostic relevance of insulin-like growth factor-I.
Hartmann BW, Laml T, Kirchengast S, Albrecht AE, Huber JC.
Department of Senology, University of Vienna Medical School, Vienna, Austria.
Many women would like to alter their breasts but are deterred by the risks involved. Silicone breast implants have been linked to a variety of illnesses, the most controversial of which are connective-tissue diseases. These circumstances urged us to perform this pilot study using a non-invasive method that involved the application of 17 beta-estradiol as it is known that estradiol enhances expression of insulin-like growth factor-I (IGF-I) which can promote growth in breast tissue. Forty-five women were included in the study. Their breast volume, IGF-I, prolactin (PRL) and estradiol levels were measured before treatment and between each application of 80 mg estradiol polyphosphate. The women's satisfaction with the results obtained was also subsequently evaluated. In 21 women (46.7%), breast size increased from 824.3 +/- 13.7 mm to 898.5 +/- 12.5 mm after 6 months. In these women a significant increase in IGF-I values was noted after 4 weeks of treatment. The increase in IGF-I values was not statistically significant in the remaining women. In addition, treatment was not successful in these women. IGF-I concentration seems to be of prognostic value as far as the response of breast tissue to estrogen stimulation is concerned. If IGF-I levels do not increase within 1 month, treatment should be discontinued. If IGF-I values do increase, this indicates that treatment is likely to be successful and can therefore be continued.
PMID: 9610425 [PubMed - indexed for MEDLINE] Logged
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member is online
Posts: 11 Re: Tissue-Engineered Breast Augmentation « Reply #2 on: 11/29/2003 at 19:06:25 »
-------------------------------------------------------------------------------- P.S. That average growth in mm converts to about 2.9 inches in six months.
Needless to say I am very interested in getting this article!! M97 Logged
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Post by Wenonae on Dec 1, 2003 11:49:30 GMT -5
M97-
GREAT SHARE!
Now, all we need to know now is how to check the IGF levels if we're having problems growing.
Is there an online test we can do? Would also be interesting to know what the "grower's" levels are.
What blocks the raising of IGF levels...hmmm.
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Post by fawnmarie on Dec 1, 2003 12:50:41 GMT -5
Wen =
Would require a blood test and some fancy justifying to your physician (unless you want to out and out pay for it).
There's some tips about raising HGH (and indirectly IGF) on my website. I.e, timing of eating, sleeping and exercise intensity. IGF is created in the liver from HGH, so a clean liver is a good idea.
Personally I use pituitary concentrate (like BO) and l'glutamine.
You can get IGF on the black market for injection, but I wouldn't go that far, myself, so I don't know where to get it.
You may be able to find an anti-aging doctor in your area that is willing to do the blood tests and the injections.
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Post by marshall97 on Dec 1, 2003 13:00:37 GMT -5
Well, I just got back from the medical library in my town, and unfortunately they don't carry this medical journal. So, I cannot elaborate on the info provided in the abstract. I was hoping to get participant info like age, etc. but I am not going to be able to get it.
If anyone else has a medical school in their town and you are interested in the article, you might call and see if it's avail. to you.
Sorry I couldn't get more info. M97
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Post by fawnmarie on Dec 1, 2003 13:34:32 GMT -5
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Post by marshall97 on Dec 1, 2003 14:01:59 GMT -5
Someone asked about IGF-1 for sale (I think on this board). I know there are several companies who manufacture recombinant and natural IGF-1 formulas including Life-Flo, Body Harmony, Renewal, NOW, etc. Go to myVitanet.com or do a search and you can find IGF-1 for sale.
I do not have any idea if the recombinant or natural IGF-1 formulas work in general (much less if they aid in BE) I am not endorsing them, just answering a question!!
I have never tried any of these IGF-1 formulas for BE! M97
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Post by Wenonae on Dec 1, 2003 15:08:23 GMT -5
Awesome discussion. Fawn- Actually, I'm going to try to finagle a blood test. Per online surveys, I think I'm hypoglycemic. I've just talked to my dr. about getting a blood test done. I've all this interest as instead of going up to double-digit 10" this mos...I'm seemingly going backwards..in fact, I KNOW I am..I just refuse to measure. I don't quite understand why this reversal of things...so I'm checking to make sure my health in other regards is fine. For the time being, I've reduced my BO dose from 1500mg to 1200mg, continuing with 800mg oregano and 1500mg damiana. We'll see what happens...I'll keep the board posted. Yeah, I don't think I'll be trying to find an anti-aging dr. Besides, we don't really know what IGF levels in specific are needed..just that it must rise for results. My timing for taking that all important last dose, I think, is on target, but I'll check your site to review it again.
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Post by gigi on Dec 1, 2003 21:02:55 GMT -5
Hi All, I have been taking l'arginine for several months because of the anti-aging benefits. L'glutamine has been added recently and I wonder what the dosage should be for the combination; currently it's 1.5g l'arginine and .5g l'glutamine. Can I titrate the l'glutamine slowly to 1.5g for a total of 3g for the combo or should it be higher because of my age? Also, can a liver cleanse with milk thistle be done concurrently? gigi BTW Since IGF-1 appears to have a profound effect on breast tissue in the study wouldn't it also impact the uterine lining and ovaries? Just wondering
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Post by Wenonae on Dec 2, 2003 17:42:09 GMT -5
Gigi- Found an interesting link on dosages...Google's great. 8-)Any other layman's recommendations would be appreciated for FYI. [ftp]http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lgl_0125.shtml[/ftp] and [ftp]http://www.theministryoffitness.com/mof/library/faq/faq6.htm[/ftp]
The thing that's tough with this research, is that probably testing was done on men, so surely it affects them differently than us, women.
Seems like ur thoughts are along the right path of no more than 1.5g's per L'. Take it slow and let us know what 'develops'
About the lining and the simultaneous cleanse...I'll defer that to Fawn or someone else who's sure. But if ur doing a cleanse, it wouldn't make as much sense to do pill-popping simultaneously, as it's going to be 'rinsed' out anyways. However, just doing the liver cleanse (epsom salts, lemon, and water) may not throw things off as much. Just thoughts.
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Post by gigi on Dec 2, 2003 20:12:31 GMT -5
Thanks Wen, The link was helpful. What I'd really like to do is see a naturopath but try to find one that's nearby and takes insurance. The closest one is a state away or 3 hours upstate according to Oxford. A hands on diagnosis is in order as there is a limit to what can be done online. Always something! The most noticeable thing about taking the combo is my sleeping. I sleep very soundly for at least 7 hours and it seems to be helping my arthritis. Of course, I just started this so there may be more positive results after a month and I will keep you informed. I'll wait on the cleanse until I know more about how to approach it. Perhaps it would make more sense to do it during my period when I cut back on my phytos anyway. gigi
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Post by SomeGirl on Dec 4, 2003 15:17:12 GMT -5
If anyone tries the IGF-1 let us know. This is interesting!
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Post by twilightsrose on Dec 5, 2003 5:01:58 GMT -5
I thought I might add to the research, but it is something negative. It is older research from 1998, and I haven't found anything to refute it yet, although I will now be looking. However, it does show how even using herbs we need to be careful in playing around with our hormones. I was thinking about trying L'Argnine myself to try raising IGF levels, hoping that it may make the difference, but now I'm not as sure:
High levels of growth hormone linked to breast cancer Discovery may help doctors to detect those most likely to develop disease From the Associated Press May 8, 1998
Young women with elevated levels of a particular growth hormone have a risk of breast cancer seven times higher than those with low levels, according to study published today.
The research is the first to find a link between this natural substance,called insulin-like growth factor, or IGF-1, and the chance of breast cancer in premenopausal women. It raises the possibility that doctors someday might screen for this hormone to help identify those at higherrisk of the disease.
American and Canadian researchers, led by Susan Hankinson of the Brigham and Women's Hospital in Boston, say further studies with greaternumbers of women are needed to better define the risk before a course ofaction can be recommended.
But if confirmed by subsequent research, the results, published in this week's issue of The Lancet, a British medical journal, could help doctors determine which women to monitor most closely to catch the disease early, said Debu Tripathy, a cancer specialist at the University of California in San Francisco.
If doctors can confirm that lowering hormone levels really does have an effect and can figure out how to achieve that result, they may be able to prevent breast cancer altogether, he said.
IGF-1, a hormone produced by most tissues in the body, is involved in normal growth but also helps cancer grow once the disease has set in. It was linked to prostate cancer in a similar study published in January.
Hankinson used blood samples of women taken in 1989 and 1990 before any of them were diagnosed. Over the next five years, the level of IGF-1 was measured in the original blood samples of the 397 women who later developed breast cancer and compared with the levels in the original samples of those 620 women who did not.
The scientists found that among the 76 premenopausal women, those with IGF-1 concentrations in the highest category had almost three times the risk of those with levels in the lowest category.
And among premenopausal women younger than 50, the risk of breast cancer for those with the highest levels of the hormone was about seven times more than for their counterparts with the lowest levels.
"The up to sevenfold increase . . . suggests that the relation between IGF-1 and risk of breast cancer may be greater than that of other established breast cancer risk factors, with the exception of a strong family history of breast cancer or a high-density mammographic profile," the study said.
The scientists found no association between the concentration of IGF-1 and the risk of breast cancer in postmenopausal women.
Although the study finds an association between IGF-1 and breast cancer, it does not speak to whether the higher hormone levels cause the disease.
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Take care, Twilightsrose
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Post by marshall97 on Dec 5, 2003 8:49:53 GMT -5
T.Rose There are many, many reports with IGF-1 and other various growth hormones and the relationship to breast cancer (and other cancers). ANYONE who is interested in IGF-1 or GH should take a look at PubMed and do a complete investigation into the research that has been done. There are negative effects reported on every herb recommended on this site, as well as BO. IGF-1 and growth hormones in general will be no exception to that! That's why all of us must be very vigilent in our research. For every "positive" report for a breast growth substance, there will undoubtedly be a "negative" one out there. I have only reported the "good" side to this issue because I make the assumption that everyone already knows that all things which mess with our hormones have, on some level, been associated w/ negative side effects. I encourage everyone to research all of the info on this site themselves. And make decisions for your own body accordingly. Thanks for pointing out the other side of things for those who might not know that RESEARCH is invaluable. I think it is important for all of us to be reminded of that fact! M97 P.S. If there is any way you can cite the reference for this article, it might be helpful for those ladies who wish to read more.
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Post by Wenonae on Dec 5, 2003 12:12:16 GMT -5
Trose,
Thanks for the contribution to this discussion. My take on GH is, if ur naturally high, then if cancer dose set it, of course, it will make u grow more mutated cells, faster.
What lots want to know here, is how to raise those levels temporarily, to help store fats in the breasts.
We've had interesting discussions on MSN BEB about cancer risks will doing something like NBE. We pretty much agreed, that temporarily, ur not doing ur body more harm, than if u were pregnant.
It's why we advocate, after a year...TAKE A BREAK!
Where'd u find ur info?
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Post by fawnmarie on Dec 5, 2003 13:57:46 GMT -5
The truth is - if you are "primed" for breast cancer - anything and everything you do for BE is going to accelerate it.
As well as increase cellular replication in cancers - IGF also increases and supports normal cellular replication. It is also responsible for growth and replication of organs, glands, etc.
Fawn
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