Tissue-Engineered Breast Augmentation

[fawnmarie]

Breast Augmentation: Exciting Possibilities For Tissue-Engineered Breast Augmentation May 13, 2000



Lake Buena Vista, Fla. (May 13, 2000) - A tissue engineering approach to breast augmentation has yielded encouraging results. Biodegradable breast implants for augmentation were constructed using a biodegradable scaffold [Poly-Glycolyco-Acid or PLGA] in conjunction with the long-term delivery of insulin and IGF-1 [Insulin Like Growth Factor]. The hypothesis being tested was whether cells could be stimulated by insulin and IGF to generate human fatty tissue to replace the biodegradable scaffold.

The results of the animal study were presented at the Annual Meeting of the American Society for Aesthetic Plastic Surgery (ASAPS) in Lake Buena Vista. The study's author, plastic surgeon Eser Yuksel, MD, says: "While research at this point is in its early stages, this study supports the conclusion that future efforts to develop a biodegradable breast implant for augmentation and for a breast prefabrication method for reconstruction following mastectomy are worth pursuing."

Total replacement by fibro-fatty tissue was observed in IGF and IGF-insulin treated groups. The utilization of different scaffolds for higher volume augmentation and computer-aided image analysis for the microscopic evaluation of tissue are currently in process. Breast augmentation is the second most requested cosmetic surgical procedure, according to ASAPS 1999 statistics. Studies have repeatedly confirmed that women who seek this procedure with realistic expectations experience improvements in body image, self-esteem and quality of life.

Co-authors: Doctors Eser Yuksel, Adam B. Weinfeld, Robert C. Cleek, John Jensen, Jacob M. Waugh, Melvin Spira, and Saleh M. Shenaq of Houston, TX

[marshall97]

Just some more data for those doing their own research. IGF-1 levels seemed to determine a postive outcome for breast growth in this study. Of course, why some of the women had increased levels of IGF-1 in response to the estrogen is not addressed, but it is an interesting correlation, nonetheless.
Sorry it is just an abstract at this point in time. I will pull the article on Monday and let you know if there is anything relevant in the remainder of the publication. This might help answer the question as to why some of us respond dramatically to herbs or BO and others of us see NO results, no matter what we do. If our bodies aren't increasing levels of IGF-1 in response to BE, that might be why we don't grow. So, then the question is--why do some women increase levels of IGF-1 in response to estrogen and others do not. I HOPE the full article will give some insight into this.
HAPPY READING!!



Gynecol Endocrinol. 1998 Apr;12(2):123-7. Related Articles, Links


Hormonal breast augmentation: prognostic relevance of insulin-like growth factor-I.

Hartmann BW, Laml T, Kirchengast S, Albrecht AE, Huber JC.

Department of Senology, University of Vienna Medical School, Vienna, Austria.

Many women would like to alter their breasts but are deterred by the risks involved. Silicone breast implants have been linked to a variety of illnesses, the most controversial of which are connective-tissue diseases. These circumstances urged us to perform this pilot study using a non-invasive method that involved the application of 17 beta-estradiol as it is known that estradiol enhances expression of insulin-like growth factor-I (IGF-I) which can promote growth in breast tissue. Forty-five women were included in the study. Their breast volume, IGF-I, prolactin (PRL) and estradiol levels were measured before treatment and between each application of 80 mg estradiol polyphosphate. The women's satisfaction with the results obtained was also subsequently evaluated. In 21 women (46.7%), breast size increased from 824.3 +/- 13.7 mm to 898.5 +/- 12.5 mm after 6 months. In these women a significant increase in IGF-I values was noted after 4 weeks of treatment. The increase in IGF-I values was not statistically significant in the remaining women. In addition, treatment was not successful in these women. IGF-I concentration seems to be of prognostic value as far as the response of breast tissue to estrogen stimulation is concerned. If IGF-I levels do not increase within 1 month, treatment should be discontinued. If IGF-I values do increase, this indicates that treatment is likely to be successful and can therefore be continued.

PMID: 9610425 [PubMed - indexed for MEDLINE]

[marshall97]

P.S. That average growth in mm converts to about 2.9 inches in six months.

Needless to say I am very interested in getting this article!!
M97

[anita22179]

hi fawn,
i have heard you say that l-arg and l-ornithine increase GH in the body and therefore increase IGF-1 which might be helpful for BE, but these supplementations are necessary only for those above 30. i was just wondering if those of us below 30 who are having difficult time to grow might benefit from l-arg and l-orth supplementation, or is it just an unnecessary waste of money for all those below 30? personally i have used BO for 2 mths and ended with lumps.
thanks,
anita

[fawnmarie]

Marshall - This is a fantastic bit of information - why don't you post it as a "stand-alone" so it doesn't get lost.

Generally, women under 30 produce enough HGH to do the job, but it may be that extra stimulation is in order. IGF is produced in the liver, so a liver cleanse might be in order too.

Depending on your budget, the supplements that stimulate HGH production may not be cost prohibitive, so it certainly can't hurt to try them, even if you are under 30.

Of course - I sell them on the website, since they are useful for several cosmetic factors (weight management, skin tone, hair health, and BE).

Some info on the subject at www.botanicalbeautylab.com/hgh.html

Products at:
www.botanicalbeautylab.com/vpantiaging.html

[kittygurl]

I personally wouldn't take too much of that stuff because I don't really want to get acromegaly.